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  1. Gene Therapy of the Central Nervous System | ScienceDirect
  2. Gene Therapy of the Central Nervous System
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Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Bridging rat sciatic nerve defects with the composite nerve-muscle autografts wrapped with human amnion matrix membrane. Neurotrophic enhancers as therapy for behavioral deficits in rodent models of Huntington's disease: Use of gangliosides, substituted pyrimidines, and mesenchymal stem cells. Google Scholar , Abstract. Glial cell transplantation and remyelination of the central nervous system.

Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord. Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS. Transplants of neuronal cells bioengineered to synthesize GABA alleviate chronic neuropathic pain. Clinical feasibility for cell therapy using human neuronal cell line to treat neuropathic behavioral hypersensitivity following spinal cord injury in rats.

Transplanted neural precursors enhance host brain-derived myelin regeneration. Human umbilical cord blood cells ameliorate Huntington's disease in transgenic mice. Parkinson's disease mice and human umbilical cord blood. Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice. Human umbilical cord blood effect on sod mice amyotrophic lateral sclerosis. Autologous hematopoietic stem cell transplantation HSCT for autoimmune diseases: Hematopoietic stem cell transplantation for multiple sclerosis.

A retrospective multicenter study. Modulation of experimentally induced epilepsy by intracerebral grafts of fetal GABAergic neurons. Embryonic stem cells and cell replacement therapies in the nervous system. Sci Paris 19 6—7: Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter. Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord. Remyelination in the CNS: From biology to therapy. Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS.

Comparative gene expression profiling of olfactory ensheathing glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheathing glia. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: Potential therapeutic application for parkinsonism. Stem Cells 24 1: Combined extrinsic and intrinsic manipulations exert complementary neuronal enrichment in embryonic rat neural precursor cultures: An in vitro and in vivo analysis.

Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation. Human umbilical cord blood treatment in a mouse model of ALS: Optimization of cell dose. Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: Distribution, migration, and differentiation.

Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: Macrophages promote axon regeneration with concurrent neurotoxicity. Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential.

Efficient expansion of mesenchymal stromal cells from umbilical cord under low serum conditions. Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitors. Fate of autologous dermal stem cells transplanted into the spinal cord after traumatic injury TSCI. Study on mesenchymal stem cells entering the brain through the blood—brain barrier.

Zhonghua Er Ke Za Zhi 42 Adipose-derived adult stem cells for cartilage tissue engineering. Human embryonic stem cells: A potential source of transplantable neural progenitor cells. Myelination and remyelination in the central nervous system by transplanted oligodendrocytes using the shiverer model. Discussion on the remyelinating cell population in adult mammals.

Transplantation of olfactory ensheathing cells stimulates the collateral sprouting from axotomized adult rat facial motoneurons. Transplantation of olfactory mucosa minimizes axonal branching and promotes the recovery of vibrissae motor performance after facial nerve repair in rats. Intra-carotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Adult stem cell therapy in stroke.

Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: Limited intraparenchymal migration and survival narrows therapeutic effects. A unique source of pluripotent stem cells for regenerative medicine. Remyelination by cells introduced into a stable demyelinating lesion in the central nervous system. Subacute neural stem cell therapy for traumatic brain injury. Schwann cells and the regrowth of axons in the mammalian CNS: A review of transplantation studies in the rat visual system.

Sertoli cells improve survival of motor neurons in SOD1 transgenic mice, a model of amyotrophic lateral sclerosis. Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke. Stereotactic implantation of fetal mesencephalon. Development and characterization of monoclonal antibodies directed against the retinal pigment epithelial cell.

Neurotrophin-mediated neuroprotection by solid fetal telencephalic graft in middle cerebral artery occlusion: Transplantation of fetal spinal cord tissue into the chronically injured adult rat spinal cord. Stem Cells 26 Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: A controlled pilot study.

Olfactory ensheathing cells transplantation for central nervous system diseases in 1, patients. Olfactory ensheathing glias transplant improves axonal regeneration and functional recovery in spinal cord contusion injury. Influence factors for functional improvement after olfactory ensheathing cell transplantation for chronic spinal cord injury. From biology to clinical translation. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice.

Current state and problems. Concurrent vasculogenesis and neurogenesis from adult neural stem cells. Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord. Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons. No To Shinkei 52 7: Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord.

Reactions of cells to the galvanic current in tissue cultures. Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord. Expression of neurotrophic factors in cultured human retinal pigment epithelial cells.

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord. Transplantation of peripheral cholinergic neurons into Alzheimer model rat brain. Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors. Pluripotency of mesenchymal stem cells derived from adult marrow.

Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase-deficient mice delays the onset of neurological abnormalities and extends their life span. The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting. Stem Cells 25 1: Human amniotic epithelial cells produce dopamine and survive after implantation into the striatum of a rat model of Parkinson's disease: A potential source of donor for transplantation therapy.

Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions. A year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells MSCs: Deep brain stimulation therapy: Control of human brain function by chronically implanted electrodes. No To Shinkei 52 4: Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.

Gene Therapy of the Central Nervous System | ScienceDirect

Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation. Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats. Genetically engineered human neural stem cells for brain repair in neurological diseases.

Autologous stem-cell transplantation in malignant multiple sclerosis: A case with a favorable long-term outcome. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results. Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury.

Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. Neurotransplantation for patients with subcortical motor stroke: Transplantation of cultured human neuronal cells for patients with stroke. Transplantation of human amniotic cells exerts neuroprotection in MPTP-induced Parkinson disease mice. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.

Transplanted hematopoietic stem cells from bone marrow differentiate into neural lineage cells and promote functional recovery after spinal cord injury in mice. Engraftment of genetically engineered amniotic epithelial cells corrects lysosomal storage in multiple areas of the brain in mucopolysaccharidosis type VII mice.

Transplants of Schwann cell cultures promote axonal regeneration in the adult mammalian brain. Efficient generation of dopamine neuron-like cells from skin-derived precursors with a synthetic peptide derived from von Hippel-Lindau protein. Functional recovery after human umbilical cord blood cells transplantation with brain-derived neutrophic factor into the spinal cord injured rat.

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Potential therapeutic clue of skin-derived progenitor cells following cytokine-mediated signal overexpressed in injured spinal cord. Reduction of cognitive deficits in rats with frontal cortex lesions. PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. A new tool in restorative neurosurgery: Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells.

Schwann cell transplantation for CNS repair. Extensive reinnervation of the hippocampus by embryonic basal forebrain cholinergic neurons grafted into the septum of neonatal rats with selective cholinergic lesions. Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease mice by modulation of immune responses.

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Stem Cells 28 2: Overexpression of Bcl-XL in human neural stem cells promotes graft survival and functional recovery following transplantation in spinal cord injury. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model.

Olfactory ensheathing cells are attracted to, and can endocytose, bacteria. Selective growth-stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Mesenchymal stem cells for ischemic stroke: Adult bone marrow transplantation after stroke in adult rats. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Intracerebral transplantation of bone marrow stromal cells in a 1-methylphenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells. Transplanted olfactory ensheathing cells incorporated into the optic nerve head ensheathe retinal ganglion cell axons: Possible relevance to glaucoma.

Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord. Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons. Intra-retrosplenial cortical grafts of cholinergic neurons: Functional incorporation and restoration of high affinity choline uptake. Intraretrosplenial cortical grafts of fetal cholinergic neurons and the restoration of spatial memory function. Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis.

Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke. Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: Implications of anti-inflammation and angiogenesis. More on restorative neurosurgery. Pharmacotherapy in restorative neurology. Olfactory mucosa autografts in human spinal cord injury: A pilot clinical study.

Olfactory mucosa for transplant-mediated repair: A complex tissue for a complex injury? Transplantation in Parkinson's disease: Two cases of adrenal medullary grafts to the putamen. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. The generation of dopaminergic neurons by human neural stem cells is enhanced by Bcl-XL, both in vitro and in vivo. Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention.

Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model. Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells. Increased expression of cyclo-oxygenase 2 and vascular endothelial growth factor in lesioned spinal cord by transplanted olfactory ensheathing cells.

Transplanted olfactory ensheathing cells modulate the inflammatory response in the injured spinal cord. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury.

Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Effect of fetal striatal and astrocyte transplants into unilateral excitotoxin-lesioned striatum. Treatment of traumatic brain injury in rats with transplantation of human amniotic cells. Neural stem cells and the quest for restorative neurology.

Autologous olfactory ensheathing cell transplantation in human paraplegia: A 3-year clinical trial. Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. Autologous stem cell transplantation as rescue therapy in malignant forms of multiple sclerosis. Dopaminergic properties of retinal pigmented epithelial cells attached to microcarriers RPE-M transplanted into parkinsonian animals.

Cellular signaling in neural stem cells: Implications for restorative neurosurgery. Syngeneic grafting of adult rat DRG-derived Schwann cells to the injured spinal cord. Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice. Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Modulation of human neural stem cell differentiation in Alzheimer APP23 transgenic mice by phenserine.

Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development. Reinnervation of peripheral nerve segments implanted into the hemisected spinal cord estimated by transgenic mice. Stem cell treatment in amyotrophic lateral sclerosis. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord.

Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: Results from an in vitro model system.

Gene Therapy of the Central Nervous System

Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Implantation of c-mycER TAM immortalized human mesencephalic-derived clonal cell lines ameliorates behavior dysfunction in a rat model of Parkinson's disease. Cellular approaches for stimulating CNS remyelination. Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: Possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease.

Transplantation of neural stem cells in a rat model of stroke: Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients. Spinal Cord 47 6: Chronic spinal injury repair by olfactory bulb ensheathing glia and feasibility for autologous therapy. Transplantation of GABAergic neurons into adult mouse neocortex. Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells.

Infusion of human umbilical cord blood ameliorates neurologic deficits in rats with hemorrhagic brain injury. Ensheathing glia transplants promote dorsal root regeneration and spinal reflex restitution after multiple lumbar rhizotomy. Therapeutic potentials of human embryonic stem cells in Parkinson's disease. Microtransplantation of dopaminergic cell suspensions: Further characterization and optimization of grafting parameters.

Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Magnetic targeting of bone marrow stromal cells into spinal cord: Transplantation of mouse induced pluripotent stem cells into the cochlea. Reinnervation of the denervated adult spinal cord of rats by intraspinal transplants of embryonic brain stem neurons. Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord. Monoaminergic reinnervation of the transected spinal cord by homologous fetal brain grafts.

Amniotic epithelial cells transform into neuron-like cells in the ischemic brain. New strategies to generate induced pluripotent stem cells. Schwann cell transplantation for repair of the adult spinal cord. Human umbilical cord blood cell grafts for brain ischemia. Inflammation and stem cell migration to the injured brain in higher organisms.

Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation. Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Transplantation of neural stem cells: Spinal implants of olfactory ensheathing cells promote axon regeneration and bladder activity after bilateral lumbosacral dorsal rhizotomy in the adult rat. Multipotent menstrual blood stromal stem cells: Improved efficacy and preservation of the neuromuscular unit', Molecular Therapy , vol.

A factor contributing to mouse strain differences in alcohol drinking? Functional implications for alcoholism', Journal of Neuroscience , vol. Lessons learned from behavioural and neurochemical studies', Behavioural Pharmacology , vol. Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice Journal of Biological Chemistry , ', Journal of Biological Chemistry , vol. Klugmann M, , 'Erratum: Spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice', Journal of Neuroscience , vol.

S69 - S69, http: Together with the B-lymphocytes, T-lymphocytes participate in the aquired immune response, which means that they are able to respond specifically to a certain pathogen. In a medical-biological context, degeneration means the decay of cells, tissues or organs. Alzheimer's disease also called Morbus Alzheimer is a slowly progressing dementia that manifests itself in an increasing reduction of brain functions.

This disease mainly affects older people. It is primarily caused by intracellular deposits of a fragment of amyloid precursor protein APP. This leads to a proceeding loss of neurons and therfore to a loss of brain mass. At the beginning of this disease, the concerned people only show a marginal obliviousness.

In later stages, speech, the ability to reason and memory are mainly affected. In the end, the concerned people lose their entire sanity and personality. Parkinson's disease also called Morbus Parkinson is a slowly progressing degenerative cerebral disease. It is caused by the loss of dopaminergic neurons in the brain, which leads to a lack of dopamine.

This causes a reduced activity of the so-called basal ganglia, which are very important for motor control. The proceeding dysfunction of the motor skill manifests itself in the typical symptoms of Parkinson like muscular rigidity, amyostasia, akinesia and posture instability. CSF is the abbreviation for colony stimulating factor. Growth factors are proteins which trigger the proliferation and the differentiation of specific cell types and tissues in an organism.

The term metabolism includes the uptake, transport, biochemical conversion and excretion of substances within an organism. These processes are necessary to build up the body mass and to meet the energy demand of the body. The opposed processes of metabolism are called anabolism and catabolism. Effectiveness of several enzymes could be catabol and anabol. Within one biochemical pathway they cannot work in both directions at the same time.

In the case of single stranded RNA, the genetic information becomes replicated after a definite period of time. Thus, eukaryotic cells detect viral dsRNA as foreign molecules and abolish them. RNA interference RNAi is a complex system within living cells of plants and animals that causes gene silencing.

Thus, plants and animals have the possibility to protect themselves against diseases caused by RNA viruses.

Publications related to this Person

In research, this mechanism is used to silence particular genes. They are complementary to the mRNA of particular genes. Due to the specific effects of this gene silencing mechanism, it is possible to discover the functions of silenced genes. Currently siRNAs are used in research studies to investigate their therapeutic capability in HIV, parkinson, cancer and other diseases. Biomolecules which can bind active agents are called targets. They can be receptors, enzymes or ion channels. If agent and target interact with each other the term agent-target-specific effect is used.

The identification of targets is very important in biomedical and pharmaceutical research because a specific interaction can help to understand basic biomolecular processes. This is essential to identify new points of application. Engrafting cells, tissue or organs from a donor into a recipient is called transplantation.

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There exist several types of transplantation which are classified in three categories: Engrafting an organ of a different species into a recipient is called xenogenic transplantation, whereas an allogenic transplantation describes the tranfer of grafts from a donor into a recipient being a member of the same species. If donor and recipient are the same individual, the transplantion is called autogenic. Furthermore there exists a syngenic transplantation which is characterized by grafts originating from the uniovular twin.

Furthermore, engrafting artificial material is called alloplastic transplantation.